Which of the following is not treated with Nifedipine?

• A. Angina
• B. Arrhythmias
• C. Hypertension
• D. Fluid retention

Answer: (D)

Nifedipine is a dihydropyridine calcium channel blocker that primarily dilates arterial smooth muscle, lowering systemic vascular resistance. This makes it effective for hypertension and for angina by reducing myocardial oxygen demand and improving coronary perfusion. It does not address fluid retention; in fact, edema is a common side effect due to arteriolar dilation increasing capillary hydrostatic pressure and fluid leakage into tissues. For rhythm disorders, nifedipine isn’t used to control heart rate or rhythm (other agents are preferred for arrhythmias). So fluid retention isn’t treated with nifedipine, which is why that option is correct.