Rapid administration of benzodiazepine may cause which adverse reaction?

• A. Hypotension
• B. Bronchoconstriction
• C. Muscle rigidity
• D. Excited delirium

Answer: (A)

Rapid IV benzodiazepines can cause a drop in blood pressure because they induce peripheral vasodilation and reduce sympathetic tone. When given quickly, the resulting decrease in systemic vascular resistance and venous return can lead to hypotension, especially in patients who are hypovolemic, elderly, or taking other depressants. In practice, administer with caution, monitor blood pressure, and be ready to support circulation and airway if needed. The other options are not typical adverse effects: benzodiazepines do not usually cause bronchoconstriction, they tend to relax muscles rather than produce rigidity, and they are used to calm agitation rather than cause excited delirium.