Lyme disease can manifest many issues including AV blocks and Neuro complications. Which systems are involved?

• A. AV blocks and Neuro complications
• B. Only joint pain
• C. Endocarditis
• D. Hepatic failure

Answer: (A)

Lyme disease can disseminate and affect multiple body systems, not just joints. The most important extra-articular manifestations involve the heart and the nervous system. Cardiac involvement can disrupt the conduction system, leading to atrioventricular blocks that range from mild to potentially severe. Neurological involvement can include meningitis, cranial nerve palsies (often facial nerve), radiculopathy, or encephalopathy. So the systems involved are the cardiovascular and nervous systems. While joint pain is common, it isn’t the only manifestation, and endocarditis or hepatic failure are not typical features of Lyme disease.